With the Increasing Incidence of Chronic Diseases, the Stem Cell Banking Industry Has Great Development Potential in the Future

Stem cells are pluripotent cells with the ability to self-replicate. Under certain conditions, it can differentiate into a variety of functional cells. Stem cells are classified as embryonic stem cells (ES cells) and somatic Stem cells according to their stage of development. According to their developmental potential, stem cells are divided into three categories: totipotent stem cells (TSC), pluripotent stem cells and unipotent stem cells. Stem cells are insufficiently differentiated and immature cells with the potential to regenerate various tissues and organs. They are called Versatile Cells in the medical field. 

A stem cell bank is a place where stem cells or related data are stored in liquid nitrogen (deep and low temperature) at approximately -196oC. A good stem cell bank should have the ability to make healthy stem cells available for clinical use anytime and anywhere. In 2020, 17.37% of the world\'s stem cell banking was used for research and disease treatment, while 82.63% was unused. 

Market Status and Forecast of Global and Korean Stem Cell banking Industry

After a period of development, the industry has entered the mature period. Globally, the Asia-Pacific region is the largest revenue market for the stem cell banking industry.  In 2020, the market revenue of the industry in the Asia-pacific region was $756.52 million, accounting for 46.21% of the global market share. North America and Europe ranked second and third with market shares of 28.73% and 21.08% respectively.  South America and Middle East and Africa accounted for 3.01% and 0.98% of the market, respectively. In addition, the future development trend of the industry in the Asia-pacific region is also good, and it is predicted that the industry will continue to develop rapidly in the next five years. It is estimated that by 2025, the market share of the region in the global market will reach 54.72%. 

The top 3 companies in the industry are Sanpower Group from China, Cord Blood Registry (CBR) and ViaCord from the United States. In 2020, the global market share of these three companies was 15.22%, 7.54% and 3.80%, respectively. The top three companies account for less than 30% of the market, indicating that the global stem cell banking industry is highly competitive with low market concentration. However, in South Korea alone, the concentration of the industry is high. In 2019, Medipost, Sewon Cellontech and CHA Biotech were the top three companies in the Korean cell bank industry with 52.35%, 11.03% and 9.10% market shares, respectively.

Data show that the total market revenue of the global stem cell bank industry in 2015 was $1295.15 million. The industry developed steadily from 2015 to 2020, and the total market value reached $1637.29 million by 2020. Based on this data, and combined with the industry development law, we carried out a series of function operations, scientific derivation of the next five years of data. Finally, it is predicted that the annual value of the global stem cell industry will continue to rise during 2021 to 2025, and will grow to $2446.74 million in 2025. 

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The Impact of the Epidemic on the Global Stem Cell Banking Industry and its Future Development Trend 

Stem cell technology has long been used to treat infectious diseases and complications. Previous attempts to treat H7N9 bird flu using stem cell technology have worked well. Therefore, a number of medical and scientific institutions in China have launched research on stem cell treatment of COVID-19. Stem cells hold promise for repairing lung tissue damage that puts critically-ill patients at risk of death and sequelae. For the treatment of COVID-19, the existing clinical application is particularly effective in rescuing critically ill cases. The mechanisms of action are multifold, including direct contact of stem cells with target cells, paracrine action, regulation of immune function, inhibition of inflammation, reduction of alveolar epithelial cell death, and promotion of lung tissue repair. 

Although it will take some time to become widely available, stem cell technology creates opportunities and options for overcoming COVID-19 or some relatively dangerous diseases. COVID-19 patients are mainly concentrated in the elderly, especially those with chronic diseases, and the main susceptibility factors are decreased body function and weakened immunity. As a result, they are more susceptible to COVID-19, and their illness is relatively accelerated and more severe. Stem cells play a key role in treating chronic diseases or COVID-19 pneumonia. As a result, the COVID-19 pandemic has boosted the use of stem cells and is largely driving the growth of the market. 

In addition, although the living standards and quality have improved significantly in recent years, there are more and more chronic diseases in the world, and the proportion of deaths caused by chronic diseases is also increasing. Chronic diseases have long course, complicated etiology and they are difficult to treat. Stem cell therapies have great potential to treat a range of common chronic diseases, including diabetes, heart disease (myocardial infarction), Parkinsons disease, spinal cord injury, arthritis, Amyotrophic lateral sclerosis, cancer, blood and immune system diseases.  Until a few years ago, there was no cure or effective treatment for these diseases. The benefits of stem cells include reversing diseases such as Parkinsons by growing new, healthy, functioning brain cells; Repairing and regenerate tissue and muscle damaged by heart disease; Addressing genetic defects by introducing normal cells; Reducing the mortality rate of patients waiting for organ transplants by regenerating healthy cells and tissue as a replacement for donated organs. Therefore, given the effectiveness of stem cells in treating chronic diseases, the rising incidence of chronic diseases is an opportunity for the stem cell banking industry. 

However, cell, tissue and biobank banks incur significant expenses in sample processing, quality testing, and sample storage and storage, not including the purchase and maintenance of high-priced instruments, reagents and consumables, which undoubtedly impose high operating costs on service providers. In addition, the increasingly strict and mandatory high ethical standards and regulatory requirements related to stem cell preservation and storage, as well as the expensive licensing and approval procedures for the establishment of stem cell banks in developed countries, are expected to further increase the overall operating costs of stem cell bank service providers, which brings some challenges to the development of stem cell bank market.

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