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With the Strong Rise of CMO Companies in Emerging Markets, the Competition in the CMO Industry Has Become Increasingly Fierce

Contract manufacturing organization (CMO) is mainly to accept the commission of pharmaceutical companies to provide process development, formulation development, clinical trial drugs, chemical or biosynthetic API production, preparation production (such as powders, injections) and packaging required for product production and other services. Pharma Contract Manufacturing Organizations (Cmos) for Injectable Drug refers to a subcategory of CMO services that provides services for Injectable Drug. Pharmaceutical contract manufacturing organizations in the injection drug industry can serve not only pharmaceutical companies, but also biotech companies. Due to the greater market demand of manufacturing companies, the market share is greater than that of biotech companies. The market share of these two application in 2019 was 75.76% and 24.24%, respectively.

Pharmaceutical contract manufacturing organizations in the injection drug industry can serve not only pharmaceutical companies, but also biotech companies. Due to the greater market demand of manufacturing companies, the market share is greater than that of biotech companies.

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Impact of COVID-19 on the Pharma Contract Manufacturing Organizations (Cmos) for Injectable Drug industry

The Asia-Pacific region is the largest market in the industry, with a market share of 39.30% in 2015 and 42.00% in 2019. North America ranks second with a market share of 29.79%. The concentration rate of the injection drug contract production industry is relatively low, and the market share of the top three companies in 2019 totaled 9.55%.

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The outbreak of COVID-19 is affecting almost every region in the world. Each region has been affected by a significant growth and demotion. Overall, the impact of the COVID-19 epidemic on the industry has more advantages than disadvantages. The outbreak of COVID-19 has inevitably affected the industry chain. The epidemic has affected all aspects of the pharmaceutical and biopharmaceutical industries, from drug development, clinical trials, supply, manufacturing to supply chain logistics. Due to limited inventory of raw materials, trade and logistics restrictions, CMO services will be difficult to operate normally. However, because drugs are an important tool for epidemic prevention and control, the overall demand for CMO services is rising. Taking WuXi AppTec as an example, the CDMO/CMO services will increase by 25.83% year-on-year in the first half of 2020. In 2020, the CMIC Group established a new subsidiary in Japan for process development and GMP production of antibody drugs using mammalian cell lines.

Pharmaceutical production requires the use of advanced technology and strict compliance with regulations, such as good manufacturing practices. After drugs are approved by regulatory authorities, pharmaceutical companies need a large supply of products for marketing and distribution. The manufacturing requirements faced by the company are huge challenges. As a result, contract manufacturing has gained popularity. By outsourcing such activities to the CMO, pharmaceutical companies can accelerate R&D activities but still generate potential revenue. Because the use of contract manufacturing and outsourcing can help large pharmaceutical companies save a lot of resources and save capital investment that would otherwise be needed for facilities and equipment. The continuous increase of the global aging population, the continuous increase in the incidence of chronic diseases, and the substantial increase in the demand for clinical injection drugs are the main driving forces that promote the rapid development of the global injection drug market. At the same time, with the development of emerging markets, China and India have huge injection drug markets. The rapid growth of international demand for injectable drugs has promoted the demand for pharmaceutical contract manufacturing organizations in the injectable drug industry.

The CMO industry is a completely competitive industry with a high degree of marketization. Since CMO companies serve mainly pharmaceutical companies in developed regions such as Europe, America and Japan, high standards of customer requirements have determined that CMO companies in Europe and the United States have become the first choice for pharmaceutical customers to choose CMO services. CMO companies in Europe and the United States have been developing for a long time, the market is relatively mature, and they have strong competitive advantages in terms of output value, growth rate and corporate level. At present, the  CMO centers are being transferred to developing countries. Emerging countries represented by China have developed rapidly in the industry by virtue of their advantages in technological competition, the improvement of cGMP quality system and the improvement of production scale. Some excellent CMO companies in emerging regions give full play to their advantages to help pharmaceutical companies effectively reduce production costs. With the strong rise of CMO companies in emerging markets, the competition in the CMO industry has become increasingly fierce.

The business model of some leading CMO companies is changing from the traditional technology transfer + customized production to the cooperative research and development + customized production model, because these companies have discovered that by deeply participating in the research and development process of innovative drugs for their customers, from the early stage of innovative drug development That is to intervene in it and deeply connect with the entire supply chain system of pharmaceutical companies such as R&D, procurement, and production. Under this model, CMO companies continue to cooperate with customers throughout the life cycle of innovative drugs, and the technical concepts and management systems of the two parties continue to run in, and they can form a deep strategic partnership. In this way, after the launch of innovative drugs, in order to ensure the quality stability and continuous and reliable supply of drugs, customers will tend to continue their previous cooperative relationships with CMO companies, thereby increasing the customer repurchase rate.

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