Laweson
reagent, or LR, is a chemical compound used in organic synthesis as a thiation
agent, which was first prepared by the reaction of aromatic hydrocarbons with
tetraphosphorus decasulfide in 1956, and was named after the Swedish chemist
Sven-Olov Laweson research on its reaction with organic compounds. It has
many advantages over the classical thionating reagent P4S10 such as mild
reaction conditions and simplicity, so it can be used to prepare thioketone,
thioester and thioamide in good yields. As an oxygen-sulfur exchange reagent,
Laweson reagent is most commonly used in the preparation of thioamides. It is conducive
to the development of the industry for its own outstanding advantages.
In terms
of purity, Laweson reagent can be divided into above 99% and 99%-95%, 99% and below
95% purity. The above 99% Laweson reagent has the highest purity and the lowest
impurity content, so it is suitable for important and precise analysis and
scientific research work. Laweson reagent with 99%-95% purity is slightly
inferior to reagents with purity above 99%, suitable for important analysis and
general research work. The purity of the Laweson reagent below 95% are quite
different from the previous two, and are suitable for school research and
general analysis work. All in all, Laweson reagent with a purity of
99%-95% can meet most of the needs with a relatively low price. Therefore, the
market is broad, with a market share of 76.27% in 2019.
Laweson reagent is widely used in several applications such as drug synthesis and material research. Its main use is the thionation of carbonyl compounds, that is, the conversion of carbonyls to thiocarbonyls, which has shown versatile properties, such as chemical selectivity and functional group tolerance. Additionally, Laweson reagent has been used to thionate enones, esters, lactones, amides, lactams and quinones, which can also react with sulfoxides to form thioproduct, then desulfurized to form thioethers. In 2019, the market share of Laweson reagent for drug synthesis and material research was 66.52% and 24.12%, respectively.
Prospect Analysis of Laweson Reagent Industry in Various Regions
After a period of development, the industry is at a growth stage. With the continuous upgrading of products and the development of technology and economy, the market continues to expand. The industrial Laweson reagent has become a competitive market, with moderate market concentration. In 2019, the top three companies, Sigma-Aldrich, Alfa Aesar, and TCL, accounted for 55.04% of the market share, which were 23.16%, 15.96% and 15.92% respectively.
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China was the largest revenue market with a market share of 43.04% in 2015 and 44.71% in 2020, an increase of 1.67%. In 2020, the Europe market share was 23.43%, ranking second. In addition, with India strong economic development, increasing downstream demand and continuous technological innovation, it is expected that India Laweson reagent market will become a growing market.
With the economic growth, scientific and technological progress, and the development of modern enterprises in APAC, it has become the bright spots for global growth and an emerging market for the Laweson reagent industry. It is set to exhibit the highest CAGR in the coming years. As Asia-Pacific countries such as China, Japan and Singapore are transforming from low-income, underdeveloped economies to modern industrial economies with higher living standards, the demand for Laweson reagent is increasing for the rapid development of chemical industry and the surge in demand for chemicals. At the same time, the rapid development of the pharmaceutical synthesis and materials research industry in the Asia-Pacific region also means that Laweson reagent has a large market potential in the Asia-Pacific region. Moreover, the increasing number of small and medium enterprises in these countries has led to high demand for Laweson reagent. In short, the large population, technological development and affluence in Asia-Pacific will promote the growth of Laweson reagent in the region, which will become the region with the highest growth rate in the forecast period.
Laweson Reagent Industry Has Great Development Potential, with a Broad Market
With the continuous development of the global economy, the increase in per capita disposable income and the continuous improvement of human living standards, the demand for Laweson reagents is getting stronger and stronger. In addition, the development of the chemical industry has played a positive role in the expansion of the Laweson reagent market.
As the incidence of diseases continues to rise, the demand for drugs has increased significantly. Innovative companies are increasingly paying attention to the development of professional drugs and the affordability of medical care, which expands the demand and consumption of the pharmaceutical synthesis industry. As the upstream raw material industry in the pharmaceutical synthesis industry, Laweson reagent industry has developed rapidly.
According
to our research, the global Laweson reagent market has a total revenue of 32.97
M USD back in 2015, and increased to 50.78 M USD in 2020. We made the prediction
that the value of Laweson reagent markets can be 86.73 M USD by 2025. The CAGR
of Laweson reagent is 9.67% from 2019 to 2025.
Although
the Laweson reagent industry has a good prospect, as its main manufacturers and
suppliers compete globally, the competition is becoming increasingly fierce,
which may become a factor hindering market growth and not conducive to the
sustainable development of the industry. In addition, there are many
alternative compounds related to Laweson reagent, which have easier use, mild
reaction conditions, and higher efficiency. The continuous development of these
substitutes has seized the market share of Laweson reagent and brought
challenges to the development of Laweson reagent industry. Therefore, higher
product quality and more affordable products will be one of the growth opportunities
in this market in the future. Only by continuous innovation can enterprises
occupy a higher market share in the fierce competition.
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